Open Access

Public RNA-seq data are not representative of global human diversity

The field of human genetics has reached a consensus that it is important to work with diverse and globally representative participant groups. This diverse sampling is required to build a robust understanding of the genomic basis of complex traits and …

How much does the unguarded X contribute to sex differences in life span?

Females and males often have markedly different mortality rates and life spans, but it is unclear why these forms of sexual dimorphism evolve. The unguarded X hypothesis contends that dimorphic life spans arise from sex differences in X or Z …